臨床分離Haemophilus influenzaeの薬剤感受性に関する検討

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  • Antimicrobial susceptibility of clinically isolated strains of Haemophilus influenzae.

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We investigated the characteristics of 178 strains of Haemophilus influenzae clinically isolated between January 1996 and April 1998, with respect toβ-lactamase production, serotype, and antimicrobial susceptibility. Of these, 4.5% were type-b strains and 87.6% were not typeable. Overall, 13.5% of the isolates producedβ-lactamase. Of the 154β-lactamase-negative H. influenzae, 4 strains (2.6%) were resistant to ampicillin (β-lactamase-negative ampicillin-resistant; BLNAR). Two strains (8.3%) of the 24β-lactamase-positive H. influenzae were resistant to amoxicillin/clavulanate (β-lactamase-positive amoxicillin/clavulanate-resistant; BLPACR). The percentages of all tested isolates composed of BLNAR, and BLPACR strains were 2.2% and 1.1%, respectively. Overall, 3.9% of the isolates were resistant to ciprofloxacin and levofloxacin. The clinical courses of the patients infected with these resistant strains were good, and no treatment failure have been found.

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