Ｓｔｒｅｐｔｏｃｏｃｃｕｓ　ｐｎｅｕｍｏｎｉａｅとＨａｅｍｏｐｈｉｌｕｓ　ｉｎｆｌｕｅｎｚａｅの混合培養系におけるｃｅｆｏｓｅｌｉｓの抗菌力

• 松本 佳巳

  藤沢薬品工業株式会社薬理研究所

• 塩川 晶子

  藤沢薬品工業株式会社薬理研究所

• 若井 芳美

  藤沢薬品工業株式会社薬理研究所

• 波多野 和男

  藤沢薬品工業株式会社薬理研究所

• 池田 文昭

  藤沢薬品工業株式会社薬理研究所

書誌事項

タイトル別名

• Efficacy of cefoselis against mixed infection caused by penicillin-resistant Strpetococcus pneumoniae (PRSP) and .BETA.-1actamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR).

抄録

Recently, penicillin-resistant Streptococcus pneumoniae (PRSP) and βlactamase-negative ampicillinresistant Haemophilus influenzae (BLNAR) are frequently being isolated from patients with respiratory tract infections in Japan, and they are often isolated at the same time. We investigated the usefulness of cefoselis (CFSL) against mixed infection caused by PRSP and BLNAR by using in vitro and in vivo models, and compared them with other antibiotics. The following results were obtained:<BR>1) CFSL had potent antibacterial activity against clinical isolates of S. pneumoniae and H. influenzae. The MIC₉₀ values of CFSL against PRSP and BLNAR were both 2μg/mL and 4 to 8 times lower than those of cefozopran (CZOP).<BR>2) CFSL showed superior bactericidal activity to CZOP against mixed cultures of PRSP and BLNAR at 1μg/mL. CFSL (1g) also exhibited potent bactericidal activity against mixed cultures of PRSP and BLNAR in an in vitro pharmacokinetic model simulating human sputum concentrations. By contrast, re-growth was observed 8 hours after dosing with CZOP (1g) and imipenem/cilastatin (IPM/CS: 0.5g).<BR>3) At a dose of 20 mg/kg CFSL had potent protective activity against mixed respiratory tract infection by PRSP and BLNAR in mice. It was more effective than CZOP, ceftazidime (CAZ), and flomoxef (FMOX), and almost as effective as IPM/CS.<BR>4) CFSL showed a potent therapeutic effect at a dose of 0.5 g in a model simulating human serum levels in mice. It was more effective than CZOP, CAZ, FMOX and IPM/CS.<BR>These results suggest that CFSL has potential for clinical use against mixed infections with S. pneumoniae and H. influenzae containing PRSP and BLNAR.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 48 (7), 516-523, 2000

  公益社団法人 日本化学療法学会

キーワード

• PRSP
• BLNAR-<I>Haemophilus influenzae</I>
• 複数菌感染

詳細情報

• CRID: 1390282681261929088
• NII論文ID: 130004102593
• NII論文ID: 10005860892
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.48.516
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2001000386
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可