黄色ブドウ球菌のｓｐａ遺伝子解析ならびに薬剤感受性の検討　メチシリン耐性株での特徴と型別分類への応用について

DOI 被引用文献1件 参考文献27件

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タイトル別名
  • Clinical analysis of Staphylococcus aureus: Relationship between the methicillin-resistance of Staphylococcus aureus and the size of the IgG binding domain in the spa gene.
  • メチシリン耐性株での特徴と型別分類への応用について

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The existence of methicillin-resistant Staphylococcus aureus (MRSA) is an important clinical problem. Staphylococcus aureus strains were isolated from 101 patients (19 outpatients and 82 inpatients) during the one-year period from July 1993 to June 1994. The mecA gene and the spa gene of these strains were analyzed by the polymerase chain reaction, and the strains were classified according to susceptibility to antibiotics, coagulase type, and phage type. Five of the 40 MRSA strains isolated produced type-5 protein A, 34 produced type-4 protein A and one produced type-3 protein A. In contrast, 38 of 61 methicillin-susceptible S. aureus (MSSA) strains produced type-5 protein A, 21 produced type-4 protein A, 2 produced type-3 protein A. The rate of expression of type-4 protein A by MRSA was significantly higher than in MSSA (p<0.001, X2=22.92). Coagulase type-H strains were the most common among the 8 serotypes (46 of 101 strains [45.5%]). Thirty coagulase type-II strains were detected among the type-4 protein A producing MRSA, but their phage types varied: 16 were untypable, 3 were type I, 1 was type I and M, 1 types I, II, and HI, 5 type HI, 2 type M and M, 1 types M and V. and 1 type V, suggesting that these strains were not of the same origin. The strains that produced type-4 protein A showed high resistance to other antibiotics. The results of this study indicated that most MRSA strains have type-4 protein A, which is uncommon in MSSA strains.

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