Ｏｆｌｏｘａｃｉｎの抜歯創移行性について　抜歯後の感染予防の検討

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  • Blood levels of ofloxacin in the extraction wounds.
  • 抜歯後の感染予防の検討

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Ofloxacin (OFLX) levels in the blood flowing from dental extraction wounds were determined, and evaluated from the aspect of antimicrobial activities. OFLX was administered to a total of 53 patients before extraction at a single dose of 100 mg. Blood samples from the extraction wounds were collected on 8mm thick paper discs and the sampling ranged from 30 minutes to 8 hours after administratin. The blood concentrations of OFLX in the extraction wounds ranged from ND (not detected) to 15.55μ g/ml. The MIC90 of OFLX against Streptococcus sp. isolated at a high frequency from odontogenic infections was 1.56μ g/ml. When the blood concentrtions in the extraction wound was set at the MIC90 as a chemoprophylactic target level, the percentage of cases achieving levels exceeding the target level was 50% between 121 and 210 minutes. It was thus concluded that OFLX should be administered 2 hours before extraction.

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