慢性気道感染症急性増悪に対する抗菌化学療法早期効果判定に関する臨床的検討

DOI 参考文献11件

書誌事項

タイトル別名
  • Clinical study of early effects of antibacterial drug treatment of acutely exacerbated chronic airwaey infections.

この論文をさがす

抄録

Clinical aspects and influence of background factors on the effects of the initial 3 days of drug treatment were studied in 92 patients examined in this department for acute aggravation of chronic airway infections between January 1994 and December 1996. The severity of infection was scored as the aggregate of the scores separately assessed for body temperature, sputum (amount, properties), leukocyte count, and Creactive protein (CRP). The effectiveness of the chemotherapy was assessed from the improvement rates measured at the start of administration, in the infection severity score (ISS), again at the third day and at the termination of treatment (the three-day and final improvement rates), and the early achievement ratio for the treatment was calculated as the former rate relative to the latter. The mean three-day and final improvement rates in the ISS in all patients were 43 ± 25% and 74 ± 22%, respectively, and resulted in a mean early effectiveness ratio of 57% for the chemotherapy. Chronic bronchitis in the infected patients showed an average three-day improvement rate of 57%, which was significantly better than the 33-43% improvement rates of bronchiectasis, diffuse panbronchiolitis, and old pulmonary tuberculosis. Sixty-nine pathogens were identified (Pseudomonas aeruginosa in 27 cases, Haemophilus influenzae in 14, Streptococcus pneumoniae in 13, Moraxella catarrhalis in 6, and methicillin-sensitive Staphylococcus aureus in 3). In the 42 cases whose pathogen was not Pseudomonas (group A), the mean three-day improvement rate was 48 ± 17% which was better than the 38 ± 22% seen in the Pseudomonas group (group B, 27 cases). The mean three-day improvement rate in the group whose etiologic agent was not identified (group C, 23 cases) was 41 ± 22%. No significant difference was observed in the three-day improvement rates for vital capacity of the lung, percent forced expiratory volume in one second, the arterial oxygen partial pressure;nor in the final improvement rate, or the early achievement ratio.

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ