中華人民共和国と日本の病院で分離されたStaphylococcus aureusの血清型と抗菌薬感受性の比較  [in Japanese] Serotypes and drug susceptibilities of Staphylococcus aureus isolated from throat and nasal vestible on medical staffs and inpatients in P. R. China and Japan  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

中国の病院関係者における<I>Staphyloococcus auresus</I>の保菌状況を調べることを目的とし, 1996年, 1997年に中国4省4都市7病院で, 健康者25人と入院患者25人を対象に咽頭と鼻前庭粘膜から<I>S. aureus</I>を分離した。分離株の血清型別および薬剤感受性を調べ, 1996年に行った東京の1病院の成績と比較した。<BR>1) 中国7病院での<I>S. aureus</I>の分離率は4%~25%であり, 東京の1病院での41.2%に比べ有意に低率であった。<BR>2) 健康者からの<I>S. aureus</I>の分離率は入院患者よりも高く, 健康者では医療従事者の方が一般人に比較し高い分離率を示した。また, 咽頭からの分離率が鼻前庭に比較して高かった。<BR>3) 中国7病院で分離された<I>S. aureus</I>の血清型はコアグラーゼVII型がもっとも多く, エンテロトキシン型は一定ではなかった。これに対して日本の1病院から分離された<I>S. aureus</I>42株のうち12株がコアグラーII型, エンテロトキシンC型であり, これらはすべてMRSAであった。<BR>4) 抗菌薬感受性について, 中国7病院での分離株はimipenem, panipenemに対する感受性が高く, tetracycline, erythromycin, roxithromycin, azithromycin には低い成績を示したが, MRSAは分離されなかった。一方, 東京の1病院では42株中17株 (40.8%) がMRSAであったが, すぺての菌株がarbekacinに4.0μg/mL以下, vanoomycinに2.0μg/mL以下のMICを示した。<BR>中国7病院と東京の1病院で分離された<I>S. aureus</I>の各種抗菌薬に対する感受性パターンの相違は, これまでの両国における感染症と治療法の差および医療体制の違いによるものと考えられるが, 西洋医学が急速に導入されている中国において, 今後の薬剤耐性菌の推移を検討する基礎資料となるであろう。

To study the prevalence of <I>Staphylococcus aureus</I> on both the throat and nasal vestibles, samples were taken from 25 healthy medical staff members and 25 inpatients at 7 hospitals in P. R. China and at a hospital in Tokyo in 1996 and 1997. Isolated <I>S. aureus</I> were examined by coagulase typing, enterotoxin typing, and drug susceptibility against 23 antimicrobials.<BR>The results were as follows;<BR>1) <I>S. auerus</I> was isolated from 4% to 25% of all sublects examined at 7 hospitals in P. R. China, showing a significantly lower rate than 42.5% at a hospital in Tokyo.<BR>2) More <I>S. aureus</I> were isolated from healthy people, especially medical staff members than from inpatients.<BR>3) The most prevalent coagulase type of <I>S. aureus</I> isolated in P. R. China, 1996 and 1997 was type VII, but their enterotoxin types were variable, indicating different sources of infections agents existing at the in hospitals. On the other hand, strains of coagulase type II with enterotoxin type C were the most prevalent at a hospital in Tokyo, showing the cross infections in a hospital.<BR>4) <I>S. aureus</I> isolated in P. R. China were the most susceptible to imipenem and panipenem, and they were the least susceptible to tetracycline, erythromycin, roxithromycin and adithromycin. There were no strains of MRSA. On the other hand, 17 strains of <I>S. aureus</I> (40.8%) were MRSA ata hospital in Tokyo and those strains were susceptible to arbekacin and vancomycin.<BR>There was a great difference between drug susceptibility against strains from P. R. China and those from Tokyo. This difference seems to come from the difference in infectious diseases, the treatments, and the medical care systems in the respective countries. However, since China is rapidly introducing Wewstern medicine, this report will serve as basic data for understanding fututre of drigresistance.

Journal

  • Japanese Journal of Chemotherapy

    Japanese Journal of Chemotherapy 47(10), 611-618, 1999-10-25

    Japanese Society of Chemotherapy

References:  20

Codes

Page Top