多型性LDL(低比重リポ蛋白)患者のHDL(高比重リポ蛋白)亜画分についての検討

J-STAGE 被引用文献5件 参考文献62件

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  • Analysis of HDL subfraction from patients with polydisperse LDL

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Serum HDL subfractions of moderate hypertriglyceridemic patients (triglyceride [TG]: 230-350 mg/dl) with mono- and polydisperse low density lipoprotein (LDL) were analyzed by 8.5% polyacrylamide gel disk electrophoresis (PAGE) and the differences in their levels and patterns were investigated for the purpose to clarify the relationship between the LDL polydispersion and HDL subfractions.<br>Patients were separated into four groups by the LDL patterns on 3% PAGE and by HDL-cholesterol levels. Monodisperse- and polydisperse LDL groups were divided into normo- and hypo-HDL cholesterolemia, respectively.<br>In conclusion, 1) In the group with polydisperse LDL or hypo-HDL cholesterolemia, small-size HDL subfractions were increased and large-size HDL subfractions were decreased, and on the whole, it was recognized that their HDL size was inclined to decrease compared to that in normo-HDL cholesterolemia with monodisperse LDL group.<br>2) In the hypertriglyceridemia groups with both of normo- and hypo-HDL choles erolemia, it was found that HDL2a in the large HDL subfractions was reduced, and HDL2b of the largest HDL subfractions and HDL3c of the smallest HDL subfractions were reversely increased beyond the levels in normo-triglyceridemia. On the whole, it was recognized that HDL subfractions were inclined to become flatter than those in normotriglyceridemia.<br>3) In patients whose serum TG was reduced by dietary treatment (restriction of total calories and sugar content), the ratios of small-size HDL subfractions (HDL3b, HDL3c) were decreased and those of HDL2a were increased with a change from polydisperse LDL to monodisperse LDL. However, mean HDL sizes were not significantly changed after dietary treatment.

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