インターフェロン投与中に抗GAD抗体が陽性化して発症したIDDMの1例

書誌事項

タイトル別名
  • IDDM Induced by Interferon Therapy with Increase of Anti-GAD Antibody. A Case Report.

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抄録

The case is a 55-year-old woman diagnosed with chronic active type C hepatitis since March, 1992 who underwent interferon (IFN) therapy at another hospital. Moreover, IFN α-2a therapy was started at the department of gastroenterology of our hospital in December 1994, and was scheduled to last for 60 weeks, however, just before its completion in December 1995, she began to complain of thirst and paresthesia of her limbs. In January 1996, her FPG level was elevated to 507mg/dl and she was admitted for insulin therapy. However, control of FPG only slightly improved, and she consulted the department of internal medicine in April 1997. At that time, urinary CPR was 8.4μg/day, anti-GAD antibody was positive-1821U/ml and because of those findings, the diagnosis of IDDM was made. We measured the change in her serum anti-GAD antibody level from before and during IFN therapy, and found it had increased at an exponential rate 8 months after the start of IFN therapy. The onset of diabetes probably occured 2 months after the elevation of the anti-GAD antibody, based on the data of 1, 5-anhydroglucitol and glycoalbumin.

収録刊行物

  • 糖尿病

    糖尿病 43 (4), 319-324, 2000

    一般社団法人 日本糖尿病学会

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