花粉症へのエメダスチンの予防，治療効果　多施設による二重盲検群間比較試験

DOI 被引用文献7件 参考文献17件

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タイトル別名
  • Effects of Emedastine on Japanese Cedar Pollinosis. A Multicentered, Double-Blind Study.
  • -A Multicentered, Double-Blind Study-
  • ―多施設による二重盲検群間比較試験―

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To evaluate the effectiveness, safety and utility of Emedastine difumarate (ED) in the treatment of Japanese cedar pollinosis, a multicentered, double-blind comparative study was performed in 290 patients in 1994.<br>Patients with Japanese cedar pollinosis were divided into two groups; the first group was treated with ED at a dose of 4mg/day starting two weeks before the season and continuing for the whole season. The second group was given an inactive placebo instead of ED during the pre-season and the early portion of the season and then replaced with ED during the later portion of the season.<br>As a result, the final improvement rate was significantly higher in the first group than that in the second group.<br>All subjective symptoms such as sneezing, nasal discharge, nasal obstruction and eye itching were suppressed due to ED treatment.<br>In conclusion, it was better to continuously administer ED to patients with pollinosis from the preseasonal period till the end of the season.<br>However, when the ED treatment was started in the midseason, the outcome was good, although less satisfactory than the outcome of continuous treatment given throughout the entire pollen season.

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