花粉症へのエメダスチンの予防,治療効果 -多施設による二重盲検群間比較試験-  [in Japanese] EFFECTS OF EMEDASTINE ON JAPANESE CEDAR POLLINOSIS -A MULTICENTERED, DOUBLE-BLIND STUDY-  [in Japanese]

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Abstract

To evaluate the effectiveness, safety and utility of Emedastine difumarate (ED) in the treatment of Japanese cedar pollinosis, a multicentered, double-blind comparative study was performed in 290 patients in 1994.<br>Patients with Japanese cedar pollinosis were divided into two groups; the first group was treated with ED at a dose of 4mg/day starting two weeks before the season and continuing for the whole season. The second group was given an inactive placebo instead of ED during the pre-season and the early portion of the season and then replaced with ED during the later portion of the season.<br>As a result, the final improvement rate was significantly higher in the first group than that in the second group.<br>All subjective symptoms such as sneezing, nasal discharge, nasal obstruction and eye itching were suppressed due to ED treatment.<br>In conclusion, it was better to continuously administer ED to patients with pollinosis from the preseasonal period till the end of the season.<br>However, when the ED treatment was started in the midseason, the outcome was good, although less satisfactory than the outcome of continuous treatment given throughout the entire pollen season.

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 88(6), 797-816, 1995-06-01

    The Society of Practical Otolaryngology

References:  17

Cited by:  6

Codes

  • NII Article ID (NAID)
    10005930750
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00326313
  • Data Source
    CJP  CJPref  J-STAGE 
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