Complementary Effects of Paeoniflorin and Glycyrrhizin on Intracellular Ca2+ Mobilization in the Nerve-Stimulated Skeletal Muscle of Mice.
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- Dezaki Katsuya
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Kimura Ikuko
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Miyahara Kayoko
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Kimura Masayasu
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
Bibliographic Information
- Other Title
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- Complementary effects of paeoniflorin and glycrrhizin on intracellular Ca2+ mobilization in the nerve-stimulated skeletal muscle of mice
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Abstract
Effects of paeoniflorin (PF) and glycyrrhizin (GLR), contained in paeony and licorice roots, respectively, on contractile and non-contractile Ca2+ mobilization were examined by measuring the Ca2+-aequorin luminescence (Ca2+ transients) of the nerve-stimulated skeletal muscle of mice in the presence of neostigmine (0.3 μM). PF (0.1-1 mM) prolonged the duration of non-contractile Ca22+ transients, which may induce the desensitization of nicotinic acetylcholine receptor, but did not affect contractile Ca22+ transients. GLR (0.3-1 mM) depressed contractile Ca2+ transients without affecting non-contractile transients. These results suggest that PF and GLR may have complementary effects on intracellular Ca2+ mobilization to block the neuromuscular transmission.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 69 (3), 281-284, 1995
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679263693312
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- NII Article ID
- 10006063469
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2MXpsFCju70%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- PubMed
- 8699638
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed