Immunological Study of Anti-M2 in Antimitochondrial Antibody-Negative Primary Biliary Cirrhosis.

• KITAMI Noriyuki

  the Department of Gastroenterology, Juntendo University School of Medicine

• KOMADA Toshiyuki

  the Department of Gastroenterology, Juntendo University School of Medicine

• ISHII Hideo

  the Department of Gastroenterology, Juntendo University School of Medicine

• SHIMIZU Hidetake

  the Department of Gastroenterology, Juntendo University School of Medicine

• ADACHI Hiroyasu

  the Department of Gastroenterology, Juntendo University School of Medicine

• YAMAGUCHI Yasushi

  the Department of Gastroenterology, Juntendo University School of Medicine

• KITAMURA Tsuneo

  the Department of Gastroenterology, Juntendo University School of Medicine

• OIDE Hirosumi

  the Department of Gastroenterology, Juntendo University School of Medicine

• MIYAZAKI Akihisa

  the Department of Gastroenterology, Juntendo University School of Medicine

• ISHIKAWA Masakuni

  the Department of Gastroenterology, Juntendo University School of Medicine

• ENDO Keiichiro

  the Department of Gastroenterology, Juntendo University School of Medicine

• WATANABE Sumio

  the Department of Gastroenterology, Juntendo University School of Medicine

• YOKOI Yukio

  the Department of Gastroenterology, Juntendo University School of Medicine

• SATO Nobuhiro

  the Department of Gastroenterology, Juntendo University School of Medicine

抄録

We investigated the specificity of various autoantibodies in antimitochondrial antibody (AMA)-negative patients with primary biliary cirrhosis (PBC). We examined sera from 144 patients with PBC, 17 of whom were AMA negative by indirect immunofluorescence. The AMA-negative group showed a significantly higher positivity for smooth muscle antibody, but not for antinuclear antibody, as compared with the AMA-positive group. IgG class anti-PDH by enzyme-linked immunosorbent assay (ELIS A) were detected in 13 % of the AM A-negative group. However, all PBC patients showed positive IgG, IgA, and/or IgM class anti-M2 to the four M2 proteins by immunoblotting. These results suggest that the detection of IgG and IgM class anti-PDH and that of antibodies to the four M2 proteins increases the positivity of this ELISA method, and that detection of IgG, IgA, and IgM class anti-M2 to the four M2 proteins by immunoblotting is useful in diagnosing AMA-negative patients with PBC.<br>(Internal Medicine 34: 496-501, 1995)

収録刊行物

• Internal Medicine

  Internal Medicine 34 (6), 496-501, 1995

  一般社団法人 日本内科学会

キーワード

• M2 protein
• pyruvate dehydrogenase complex
• protein X
• antinuclear antibody
• smooth muscle antibody
• anticentromere antibody

詳細情報

• CRID: 1390282679845901568
• NII論文ID: 10006168056
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.34.496
• COI: 1:STN:280:BymD3M3jslI%3D
• ISSN: 13497235
• ISSN: 09182918
• ISSN: http://id.crossref.org/issn/09182918
• PubMed: 7549131
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/34/6/34_6_496/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996024793
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可