ＡＭＬへの進展過程でｔ（３；２１）（ｑ２６；ｑ２２）転座が出現しＡＭＬ１／ＥＶＩ１キメラｍＲＮＡが検出されたＭＤＳ

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タイトル別名
  • Detection of t(3;21)(q26;q22) with AML1/EVI1 mRNA during Progression of Myelodysplastic Syndrome to Acute Myeloid Leukemia.
  • AML エ ノ シンテン カテイ デ t 3 21 q26 q22 テンザ ガ シュツゲン シ AML1 EVI1 キメラ mRNA ガ ケンシュツ サレタ MDS

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A 74-year-old woman had myelodysplastic syndrome (MDS) in 1986. In June 1994, she suffered exacerbation of pancytopenia with no chromosomal abnormalities, but AML1/EVI1 chimeric mRNA was detected by RT-PCR. Two months later, an increase in bone marrow blasts (5%) was noted, and chromosomal analysis detected t(3;21)(q26;22), del(7)(q22), del(11)(q23). In 1995, the marrow blasts increased to 30% and the patient died of disease progression. The AML1/EVI1 gene has been shown to cause blast crisis in chronic myelogenous leukemia. This case suggested that the AML1/EVI1 gene may be involved in the progression of MDS together with del(7)(q22) and del(11)(q23).

収録刊行物

  • 臨床血液

    臨床血液 40 (6), 518-520, 1999

    一般社団法人 日本血液学会

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