IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia.

DOI Web Site PubMed 被引用文献5件 参考文献13件
  • YAMAGUCHI Shinji
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • OKUBO Yoshio
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • HOSSAIN Mahboob
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • FUJIMOTO Keisaku
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • HONDA Takayuki
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • KUBO Keishi
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • SEKIGUCHI Morie
    the First Department of Internal Medicine, Shinshu University School of Medicine
  • TAKATSU Kiyoshi
    the Department of Immunology, Institute of Medical Science, University of Tokyo

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We describe an acute eosinophilic pneumonia (AEP) patient with bronchoalveolar lavage fluid (BALF). Eosinophil cell number (47%), content of interleukin (IL)-5 (8.22×102 pg/ml) and eosinophil cationic protein (9.25 μg/ml) were high in BALF. No eosinophilia was seen in peripheral blood on admission; however, content of IL-5 was 9.47×102 pg/ml. After methylprednisolone pulse therapy, he improved rapidly with a reduction in eosinophil cell number (7%) and the content of IL-5 (<100 pg/ml) in BALF. However, a high content of IL-5 (6.9×102 pg/ml) and transient eosinophilia (17.5%) were seen in peripheral blood. It is important to distinguish between AEP and infectious pneumonia, because of the differing treatments. If the diagnosis of AEP is doubtful, BALF should be performed early.<br>(Internal Medicine 34: 65-68, 1995)

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  • Internal Medicine

    Internal Medicine 34 (1), 65-68, 1995

    一般社団法人 日本内科学会

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