Induction Therapy with All-Trans Retinoic Acid for Acute Promyelocytic Leukemia: A Clinical Study of 10 Cases, Including a Fetal Case with Thromboembolism.

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  • TSUKADA Nobuhiro
    The First Department of Internal Medicine, Niigata University School of Medicine
  • WADA Ken
    The First Department of Internal Medicine, Niigata University School of Medicine
  • AOKI Sadao
    The First Department of Internal Medicine, Niigata University School of Medicine
  • HASHIMOTO Shigeo
    The First Department of Internal Medicine, Niigata University School of Medicine
  • KISHI Kenji
    The First Department of Internal Medicine, Niigata University School of Medicine
  • TAKAHASHI Masuhiro
    The First Department of Internal Medicine, Niigata University School of Medicine
  • KOIKE Tadashi
    The First Department of Internal Medicine, Niigata University School of Medicine
  • TAKAHASHI Hoyu
    The First Department of Internal Medicine, Niigata University School of Medicine
  • SHIBATA Akira
    The First Department of Internal Medicine, Niigata University School of Medicine

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Ten patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Eight of 10 patients achieved complete remission (CR), and among the 8 newly diagnosed cases, 7 achieved CR. Five of 8 CR cases remained in CR after 8 to 30 months. Except for hypotension and a large gastric ulcer resulting from hyperhistaminemia, the adverse effects of ATRA were generally mild. Severe thrombotic tendency occurred in a patient treated with ATRA combined with tranexamic acid. Intensive chemotherapy consisting of daunorubicin (DNR) and other agents was scheduled for the patients who achieved CR with ATRA.<br>(Internal Medicine 35:10-14, 1996)

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  • Internal Medicine

    Internal Medicine 35 (1), 10-14, 1996

    一般社団法人 日本内科学会

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