Changes in the Hepatitis B Virus Precore and Core Regions in Association with the Disappearance of Hepatitis B e Antigen in Patients with Chronic Hepatitis B.
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- NAKAYAMA Junko
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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- NAKANISHI Toshio
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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- ARATAKI Keiko
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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- OBATAKE Toshiyuki
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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- MORIYA Takashi
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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- KAJIYAMA Goro
- the First Department of Internal Medicine, Hiroshima University School of Medicine
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Disappearance of the hepatitis B e antigen (HBeAg) typically signals the remission of chronic hepatitis B; however, HBeAg defective variants have been identified in patients with HBeAg negative chronic hepatitis (CH). We studied the changes in the hepatitis B virus (HBV) genome associated with HBeAg clearance in four asymptomatic carriers (ASC) and in four patients with CH. Three ASC had a precore stop codon variant with the core region being wild-type or deleted. The other ASC had wild-type precore and core region. In all ASC, HBV levels were reduced markedly with two ASC converting HBV negative status via polymerase chain reaction. In contrast, patients with CH had continued high titers of HBV. In two patients, the precore region remained wild-type, but the core region contained a cleavage site mutation or was deleted. The precore variant was present in both ASC and CH, perhaps suggesting that it does not significantly influence hepatitis B activity.<br>(Internal Medicine 34: 319-325, 1995)
収録刊行物
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- Internal Medicine
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Internal Medicine 34 (5), 319-325, 1995
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204867383168
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- NII論文ID
- 10006803602
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:ByqA2srjs1U%3D
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- ISSN
- 13497235
- 09182918
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- PubMed
- 7647395
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可