胃内４点生検によるＨｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉ胃内分布の検討

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  • Helicobacter Pylori Infection in the Cardia of the Stomach.

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The aikm of this study was to analyze the Helicobacter pylori(Hp)infection in the cardia. According to our protocol, four biopsy specimens were obtained from the antrum, the lower body, the upper body, and the cardia on the greater curvature using different forceps. Each specimens were streak on the selective medium. Age distribution of Hp positive patients in all 4 biopsy sites had a peak in forties, and uneven Hp distribution on gastric mucosa increased with age. Negative rates of each biopsy site in Hp positive patients were 28% in th eantrum and the cardia, and 11% in the lower and upper body. There were 15 Hp positive patients sequentially positive from the antrum to the oral side, 13 patients from the cardia to the anal side. There were 21 patients of Hp intermittently positive among 4 biopsy sites. In five of them Hp was positive in the cardia and the antrum, in 16 of them in the lower and upper body. It was considered that the first Hp infection of the stomach should occur not only in the antrum but also in the cardia. Most of patients with duodenal ulcer were Hp positive in all 4 biopsy sites, and a lot of parients with gastric ulcer were Hp positive in the fundic gland area of the stomach. There was no correlation between Hp distribution on gastric mucosa and the positive rate and the level of HplgG antibody.

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