αおよびβ交感神経刺激剤のメサコリン誘発ヒト鼻汁分泌動態に及ぼす影響

DOI PubMed 参考文献61件
  • 森下 篤人
    桑名市民病院耳鼻咽喉科 三重大学医学部耳鼻咽喉科学教室

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  • EFFECT OF ALPHA AND BETA-ADRENERGIC AGONISTS ON METHACHOLINE-INDUCED NASAL SECRETION IN MAN

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To examine the roles of α-adrenergic, β-adrenergic and cholinergic agonists on the nasal secretion mechanism, the author repeated nasal methacholine (Mch, 1 time 20mg) challenges ten times at 10-min intervals in 13 healthy male subjects. As it was difficult to obtain a sufficient amount of nasal secretion for analysis using simple nasal provocation tests with α-and β-adrenergic agonists before repeated Mch challenges, α-adrenergic (phenylephrine, Phe, 2mg) and β-adrenergic (isoproterenol, Iso, 0.2mg) agonists were administered into both nostrils. The effects of these agents on the volume of nasal secretions (Vol), the fucose volume (Fu, an index of glandular secretion) and the albumin volume (Alb, an index of vascular permeability) in the Mch induced nasal secretions were analyzed each time. Repeated Mch challenges revealed that the initial challenge produced the largest response as reflected by the Vol, Fu and Alb of the secretions, and by Vol and Fu production being almost constant during the 10 repetitions of Mch challenge at 10-min intervals. However, Alb demonstrated the greatest decrements. Phe administration before Mch challenges gave rise to Fu increasing more markedly while Alb was unchanged. On the other hand, that of Iso before, produced greater decreases in Vol, Fu and Alb levels. Therefore, it is suggested that repeated Mch challenge causes the maintenance of glandular secretion while stopping albumin permeability, that with pre-administration of α-agonists glandular secretion increases, and that pre-administration of β-agonists inhibits glandular secretion. When both α-and β-agonists are given before the challenge, however, there is no increase in vascular permeability.

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