発酵液直接処理型イオン交換樹脂操作法の開発

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タイトル別名
  • New Ion Exchange Resin Operation for Downstream of Bioprocess.
  • ハッコウエキ チョクセツ ショリガタ イオン コウカン ジュシ ソウサホウ ノ カイハツ

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抄録

A new ion exchange resin operation system which can treat fermentation broth without any pretreatment is studied. In a conventional fixed bed column pretreatment such as membrane or centrifugal separation is required in order to prevent the clogging of bacteria in the resin layer inside. However these processes require higher capital investment and lower the yield.<BR>The new method solves these problems by treating ion exchange resin as slurry. No problem is observed in pilot scale experiments using lysine fermentation broth. The bacteria do not clog the resin phase, and elute is not contaminated, even if the bacteria concentration of the feed fermentation broth is very high (10 vol%). In addition, it is found that the amount of washing water in the new method is less than that of the conventional method.<BR>A simple numerical simulation model is also proposed and evaluated. The numerical value expresses good agreement with the experimental value, and it is proved that this model can be used for optimization of process design.

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