Lactic Dehydrogenase-Immunoglobulin G.KAPPA. Complex in a Patient with Idiopathic Interstitial Pneumonia.

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  • FUJISHIMA Takuya
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • MORITA Shiho
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SHIJUBO Noriharu
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • NAKATA Hisashi
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SHIGEHARA Katsunori
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KOBA Hiroyuki
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
  • ABE Shosaku
    The Third Department of Internal Medicine, Sapporo Medical University School of Medicine

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Abstract

A female patient with idiopathic interstitial pneumonia (IIP) was admitted again 40 months after the diagnosis due to progression of clinical findings and increased activity of serum lactic dehydrogenase (LDH). Analysis of LDH isoenzyme disclosed a broad band between LDH4 and LDH5. Gel filtration and immunoelectrophoresis showed that immunoglobulin (Ig) G (κ type) bound the LDH. With prednisolone and azathioprine, her symptoms and radiological findings improved concomitant with a decrease in the serum LDH activity. The LDH-IgGκ complex disappeared in the circulation 14 months after initiation of the therapy. We report circulating LDH-Ig complex in a patient with IIP, which may be related to the disease progression of IIP. <br>(Internal Medicine 35: 413-415, 1996)

Journal

  • Internal Medicine

    Internal Medicine 35 (5), 413-415, 1996

    The Japanese Society of Internal Medicine

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