Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis.

• HORIE Shiro

  The First Department of Internal Medicine, Shinshu University School of Medicine

• OKUBO Yoshio

  The First Department of Internal Medicine, Shinshu University School of Medicine

• HOSSAIN Mahboob

  The First Department of Internal Medicine, Shinshu University School of Medicine

• SATO Etsuro

  The First Department of Internal Medicine, Shinshu University School of Medicine

• NOMURA Hiroshi

  The First Department of Internal Medicine, Shinshu University School of Medicine

• KOYAMA Sekiya

  The First Department of Internal Medicine, Shinshu University School of Medicine

• SUZUKI Jun-ichi

  The First Department of Internal Medicine, Shinshu University School of Medicine

• ISOBE Mitsuaki

  The First Department of Internal Medicine, Shinshu University School of Medicine

• SEKIGUCHI Mode

  The First Department of Internal Medicine, Shinshu University School of Medicine

書誌事項

タイトル別名

• Interleukin 13 but Not Interleukin 4 Pr

抄録

The effects of recombinant human (rh) interleukin (IL)-4 or rhIL-13 on survival, and chemotactic activity of human eosinophils were examined. Only rhIL-13 prolonged eosinophil survival in a dose-dependent manner above 3 ng/ml. Eosinophil survival induced by rhIL-13 was inhibited by monoclonal antibodies (mAbs) against IL-3 (p<0.01) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p<0.05), suggesting that rhIL-13 induced IL-3 and GM-CSF production from eosinophils and an autocrine mechanism is responsible for the eosinophil survival. The effects of rhIL-13 on eosinophil chemotactic activity were also examined. rhIL-13 showed chemotactic activity for eosinophils in a dose-dependent manner. Checkerboard analysis revealed that eosinophil migration was dependent on the concentration gradient, confirming that rhIL-13 is a chemotactic factor. rhIL-4 showed no effects. IL-13 may play an important role in the survival and recruitment of eosinophils in allergic diseases.<br>(Internal Medicine 36: 179-185, 1997)

収録刊行物

• Internal Medicine

  Internal Medicine 36 (3), 179-185, 1997

  一般社団法人 日本内科学会

キーワード

• cytokine
• eosinophil recruitment

詳細情報

• CRID: 1390001204866753408
• NII論文ID: 10007005681
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.36.179
• COI: 1:CAS:528:DyaK2sXktFGqsL0%3D
• ISSN: 13497235
• ISSN: 09182918
• NDL書誌ID: 4220041
• PubMed: 9144009
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4220041
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/36/3/36_3_179/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997195078
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可