Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning.

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  • ARAI Aki
    The Department of Neurology, Brain Research Institute, Niigata University
  • SATO Masahisa
    The Department of Neurology, Brain Research Institute, Niigata University
  • HOZUMI Isao
    The Department of Neurology, Brain Research Institute, Niigata University
  • MATSUBARA Nae
    The Department of Neurology, Brain Research Institute, Niigata University
  • TANAKA Keiko
    The Department of Neurology, Brain Research Institute, Niigata University
  • SOMA Yoshiaki
    The Department of Neurology, Brain Research Institute, Niigata University
  • ADACHI Tetsuo
    The Department of Internal Medicine, Funae Hospital
  • TSUJI Shoji
    The Department of Neurology, Brain Research Institute, Niigata University

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  • Cerebellar Ataxia and Peripheral Neurop

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A patient with chronic bromvalerylurea poisoning showed cerebellar ataxia and peripheral neuropathy. The patient was a 42-year-old Japanese man who developed consciousness disturbance, diplopia, slurred speech, ataxia and gait disturbance after having taken bromvalerylurea for ten years. Magnetic resonance imaging revealed atrophy of the cerebellum and pontine tegmentum. An electrophysiological study revealed decreased motor nerve conduction velocity and amplitude of compound muscle action potentials of the right tibial nerve. Histological findings of the left sural nerve indicated a slightly decreased large myelinated fiber diameter, which suggested chronic axonal damage.<br>(Internal Medicine 36: 742-746, 1997)

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  • Internal Medicine

    Internal Medicine 36 (10), 742-746, 1997

    一般社団法人 日本内科学会

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