書誌事項
- タイトル別名
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- Colitis enhances the colorectal carcinogenesis in rats: Correlation between the incidence of aberrant crypt foci and the incidence of tumors.
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抄録
We examined the implication of colitis on the colorectal carcinogenesis in rats. We used 1, 2-dimethylhydrazine (DMH) as a carcinogen and trinitrobenzenesulfonic acid (TNB) as a colitis-inducing agent on F344 rats. After treating the rats with DMH, TNB markedly enhanced the incidence of aberrant crypt foci (ACF), putative preneoplastic lesions, as well as colon cancers in the rats (p<0.01). There was positive correlation between the incidence of ACF and the incidence of tumors. Furthermore, we treated the rats with two different anti-inflammatory drugs (a non-steroidal anti-inflammatory drug:Fenbufen and a platelet activating factor-receptor antagonist:PAF-RA) after pre-treatment with DMH and TNB. Only PAF-RA significantly decreased the incidence of ACF in the rats (p<0.05).
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 98 (5), 525-532, 2001
一般財団法人 日本消化器病学会
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詳細情報 詳細情報について
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- CRID
- 1390282681372149760
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- NII論文ID
- 10007031483
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- NII書誌ID
- AN00192124
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- COI
- 1:STN:280:DC%2BD3Mzjt1Okuw%3D%3D
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- ISSN
- 13497693
- 04466586
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- PubMed
- 11400280
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可