高出力半導体レーザーにICGを併用した内視鏡治療法の検討 (1)  摘出ブタ胃および開腹下イヌ胃に対する照射

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タイトル別名
  • Enhanced Diode Laser Ablation Using Submucosal Injection of Indocyanine Green Solution. Part I. Irradiation to the Resected Porcine Gastric Walls and Canine Gastric Walls Under Laparotomy.
  • IRRADIATIGN TG THE RESECTED PGRCINE GASTRIC BALLS AND CANINE GASTRIC WALLS UNDER LAPAROTOMY
  • ―摘出ブタ胃および開腹下イヌ胃に対する照射―

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High-power diode laser ablation with indocyanine green(ICG)solution injection to thesubmucosal layer was evaluated for the treatment of early gastric cancer. The diode laserbeam with 805nm in wavelength was irradiated to the resected porcine gastric wall andcanine gastric wall under laparotomy with ICG solution(1 mg/ml)injection. The injectedICG solution was used to enhance the tissue absorption of the submucosa to the diode laseremission. The gastric wall with 5%glucose solution injection was also prepared tocompare the ablation characteristics. Using 12 or 25 W of the laser power with 2mmdiameter beam, we found the ICG injected submucosa was completely ablated by the diodelaser radiation. We could apply the high intensity diode laser beam, because ICG dyedlayer prevented direct laser penetration to muscularis propriae. Although the laser irradiation easily removed the mucosal layer in the ease with saline injection, it could not ablatedthe submucosa with 12 W. We could easily judge the ablated depth by surface color change.When ICG dyed submucosal layer was completely removed, the muscularis propriae wasrecognized by thin brawn color. we think these findings were extremely important, because we can prevent gastric perforation by endoscopic observation of color change ofthe ablated surface.

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