書誌事項
- タイトル別名
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- Pharmacodynamics Effects of Antibiotics in Hypothermia In Vitro.
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We studied the pharmacodynamics of antibiotics at 32°C and 37°C in vitro which meant the bactericidal activity (1/2MIC, 1MIC, 2MIC, and 4MIC) to methicillin susceptible Staphylococcus aureus (MSSA), methicillin resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (P. aeruginosa) separated from clinical materials. Bacterial proliferation without antibiotics at 32°C was inhibited more than that at 37°C. The bactericidal activity of cefazolin (CEZ) and piperacillin (PIPC) for MSSA did not differ at 32°C and 37°C. Just 4MIC of CEZ and PIPC prevented bacterial proliferation at both temperatures. The bactericidal activity of arbekacin (ABK) and vancomycin (VCM) for MRSA were stronger at 32°C than 37°C. The bactericidal activity of ABK depended on the inhibitory concentration of antibiotics and that of VCM was apparent in 2MIC at 32°C. The action of VCM, maintained from 8 to 24 hours, differed from that of ABK. ABK was the most bactericidal activity in ABK, ceftazidime (CAZ), cefazopran (CZOP), and panipenem (PAPM) for P. aeruginosa. The bactericidal activity of ABK for P. aeruginosa showed a stronger tendency in antibiotic concentration than that of MRSA. The bactericidal activity of 3 antibiotics except for PAPM at 37°C was stronger than that at 32°C in 1MIC, but the reverse in 4MIC. These results suggest that the bactericidal activity of antibiotics may change under the influence of MIC and temperature.
収録刊行物
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- 日本救急医学会雑誌
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日本救急医学会雑誌 12 (2), 43-53, 2001
一般社団法人 日本救急医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204371019776
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- NII論文ID
- 130003437599
- 10007078480
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- NII書誌ID
- AN10284604
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- ISSN
- 18833772
- 0915924X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可