The Role of Oxygen-Derived Free Radicals in Augmented Relaxations to Levcromakalim in the Aorta From Hypertensive Rats.
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- Kinoshita Hiroyuki
- Department of Anesthesia, Japanese Red Cross Society Wakayama Medical Center
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- Kakutani Tetsuya
- Department of Anesthesiology, Wakayama Medical Collage
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- Iranami Hiroshi
- Department of Anesthesia, Japanese Red Cross Society Wakayama Medical Center
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- Hatano Yoshio
- Department of Anesthesiology, Wakayama Medical Collage
Bibliographic Information
- Other Title
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- Role of Oxygen Derived Free Radicals in Augmented Relaxations to Levcromakalim in the Aorta From Hypertensive Rats
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Abstract
Hydrogen peroxide and peroxynitrite induce relaxations via ATP-sensitive K+ channels, indicating that oxygen-derived free radicals may activate these channels. Levels of free radicals are increased throughout the arterial wall in animal models of atherosclerosis, and therefore, vasorelaxation via ATP-sensitive K+ channels may be augmented in chronic hypertension. The present study was designed to determine whether relaxations to an ATP-sensitive K+ channel opener, levcromakalim, are increased in the aorta from spontaneously hypertensive rats (SHR) and whether free radical scavengers reduce these relaxations. Rings of aortas without endothelium taken from age-matched Wistar-Kyoto rats (WKY) and SHR were suspended for isometric force recording. Relaxations to levcromakalim (10-8 to 10-5 M), which are abolished by glibenclamide (10-5 M), were augmented in the aorta from SHR, compared to those in the aorta from WKY. In the aorta from SHR, catalase (1200 U/ml), but neither superoxide dismutase (150 U/ml) nor deferoxamine (10-4 M), reduced relaxations to levcromakalim, whereas in the aorta from WKY, the free radical scavengers did not affect these relaxations. These results suggest that in chronic hypertension, vasorelaxation to an ATP-sensitive K+ channel opener is augmented and that hydrogen peroxide produced in smooth muscle cells may partly contribute to these relaxations.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 85 (1), 29-33, 2001
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204284558080
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- NII Article ID
- 10007119312
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXotVOrtQ%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 5645711
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- PubMed
- 11243571
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- Web Site
- http://id.ndl.go.jp/bib/5645711
- https://ndlsearch.ndl.go.jp/books/R000000004-I5645711
- https://api.elsevier.com/content/article/PII:S0021519819304676?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819304676?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2001139276
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed