微粒子製剤設計とＤＤＳ　　生体内分解性高分子のＤＤＳ製剤への応用

• 小川 泰亮

  聖マリアンナ医科大学難病治療研究センター

書誌事項

タイトル別名

• Microcapsules prepared with biodegradable polymer for prolonged release of drugs.
• Microcapsules prepared with biodegradable polymer for prolonged release of drugs
• 生体内分解性高分子のDDS製剤への応用

抄録

Microencapsulation techniques, phase separation and solvent evaporation, have been developed for preparation of drug-containing monolithic microcapsules for prolonged release using poly(lactide-co-gtycolide) and copoly(lactic/glycolic) acid. A new technique encapsulating highly water-soluble drugs has been established by modifying the solvent evaporation method using a w/o/w emulsion. The method can completely entrap the highly water-soluble drugs into the microcapsules and can easily prepare the microcapsules in a large scale. The drug releases in a pseudozero order kinetics for several weeks with degradation of the polymers after an initial burst release. Many prolonged release-microcapsules containing water-soluble peptides and proteins were prepared by this method. It is difficult to avoid the initial burst release from the microcapsules containing a water-soluble drug, and a technique to avoid the burst has not been found yet. But an insulin-microcapsule system without the initial burst release has just been presented in the DDS meeting in Japan in this summer. The initial burst problem will be solved in near future.

収録刊行物

• Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ

  Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ 15 (5), 429-436, 2000

  日本DDS学会

キーワード

• microcapsule
• copoly(lactic/glycolic)acid
• PLGA
• method

詳細情報

• CRID: 1390282679617602944
• NII論文ID: 10007334534
• NII書誌ID: AN10084591
• DOI: 10.2745/dds.15.429
• ISSN: 18812732
• ISSN: 09135006
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可