Blunt Cell Growth Potential in Carcinogen Resistant Inbred DRH Rats.
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- YAMASHIRO Kenzo
- Department of 3rd Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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- YAN Ying
- Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health
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- FUKAMACHI Yukiyo
- Department of 2nd Surgery, School of Medicine, Tokyo Women's Medical University
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- GOTOH Sadao
- Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health
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- HIGASHI Ken
- Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health
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- OHTSUKI Makoto
- Department of 3rd Internal Medicine, School of Medicine, University of Occupational and Environmental Health
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- HAMADA Yuji
- Seac Yoshitomi, Ltd.
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- HIGASHI Taneaki
- College of Nutrition, Koshien University
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A carcinogen-resistant inbred strain DRH/Sea has been developed from the Crj:Donryu strain. The rats had a very low incidence of liver tumors when they were fed diets containing a hepatocarcinogen such as 3'-methyl-4-dimethylamino-azobenzene (3'-Me-DAB). Despite using 3'-Me-DAB during the stage of selection, the DRH/Sea rats developed normally, reproduced and did not have any spontaneous tumor in the lung, liver or uterus at over 1 year of age. Although their growth curves were similar to the Crj:Donryu rats, the progression of polyploidization in the liver was significantly delayed when compared with Crj:Donryu rats. Mitogenic changes that occurred in the liver caused by either 3'-Me-DAB or lead nitrate were less significant in the DRH rats than in Crj:Donryu rats. Furthermore, the growth rate of cultured fibroblasts derived from the DRH rats was slower than that of Crj:Donryu rats. These results, together with our previous results, suggest that slow growth potential is present under certain conditions in DRH rats. These findings may explain partly the meaning of the different susceptibility to hepatocarcinogens.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 49 (1), 47-50, 2000
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205040980992
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- NII論文ID
- 10007343269
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 4960276
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- PubMed
- 10803362
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可