Hematological Characteristics of Rats Spontaneously Developing Eosinophilia.
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- MATSUMOTO Kiyoshi
- Institute of Experimental Animals, Shinshu University School of Medicine
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- MATSUSHITA Norifumi
- Institute of Experimental Animals, Shinshu University School of Medicine
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- TOMOZAWA Hiroshi
- Institute of Experimental Animals, Shinshu University School of Medicine
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- TAGAWA Yoh-ichi
- Institute of Experimental Animals, Shinshu University School of Medicine
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Hematological and genetic characteristics of newly found eosinophilic rats were studied. Hematologically, high blood eosinophil counts started at 6 weeks of age. Almost all 10-week-old rats had eosinophilia with individual counts above 500/μl and 5 to 100 times the normal level. Proliferating eosinophils had normal morphology. An increase in lymphocyte counts was observed at 5 weeks of age, one week earlier than the onset of eosinophilosis. In bone marrow, proliferation of eosinophils was also observed at 8 weeks of age and thereafter progressed, suggesting a role in the pathogenesis of eosinophilia in this rat. The results of genetic cross experiments revealed the disease to be hereditary. The spontaneously eosinophilic rat therefore warrants attention as a model for studying the underlying mechanisms of human and animal eosinophilia.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 49 (3), 211-215, 2000
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390282680019808256
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- NII論文ID
- 10007343885
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- NII書誌ID
- AA11032321
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- COI
- 1:STN:280:DC%2BD3M%2FmsFSltg%3D%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 5457636
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- PubMed
- 11109544
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可