A Novel Analgesic Compound OT-7100 Attenuates Nociceptive Responses in Animal Models of Inflammatory and Neuropathic Hyperalgesia: A Possible Involvement of Adenosinergic Anti-nociception.
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- Yasuda Tsuneo
- Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
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- Okamoto Keiichiro
- Department of Anatomy and Neurobiology, Wakayama Medical University
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- Iwamoto Takeshi
- Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
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- Miki Shinya
- Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
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- Yoshinaga Norihiro
- Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
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- Sato Seiji
- Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
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- Noguchi Koichi
- Department of Anatomy and Neuroscience, Hyogo College of Medicine
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- Senba Emiko
- Department of Anatomy and Neurobiology, Wakayama Medical University
書誌事項
- タイトル別名
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- Novel Analgesic Compound OT 7100 Attenuates Nociceptive Responses in Animal Models of Inflammatory and Neuropathic Hyperalgesia A Possible Involvement of Adenosinergic Anti nociception
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We studied the effects of OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo [1,5-a]pyrimidine), a novel analgesic compound, on the inhibitory action of adenosine on the contraction of guinea pig ileum and investigated the effects of OT-7100 on the nociceptive responses in animal models of inflammatory and peripheral neuropathic hyperalgesia and decreases spinal c-Fos expression. OT-7100 at 0.3 – 3 μM significantly enhanced the inhibitory effect of adenosine on the contraction of guinea pig ileum. The efficacy of OT-7100 (1, 3 or 10 mg/kg, p.o.) on hyperalgesia induced by yeast or substance P and in the Bennett model was significantly suppressed by coadministration of the adenosine A1 antagonist DPCPX (0.01 or 0.1 pmol/animal, i.t.), while OT-7100 without DPCPX significantly increased the nociceptive threshold in each rat model. OT-7100 (3, 10 and 30 mg/kg per day, p.o.) significantly inhibited the mechanical nociceptive threshold in the injured paw in the Chung model. OT-7100 (30 mg/kg, p.o.) significantly decreased the number of Fos-LI neurons in the spinal dorsal horn in the Bennett model. These finding suggest that OT-7100 inhibits hyperalgesia in these animal models possibly by enhancing adenosinergic neurotransmission in the dorsal horn, although we still lack direct evidence for it.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 87 (3), 214-225, 2001
公益社団法人 日本薬理学会
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詳細情報
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- CRID
- 1390001204285365888
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- NII論文ID
- 10007368463
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXovVylsbw%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5984889
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- PubMed
- 11885971
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可