フィナステリドの高齢者における体内動態

• 石井 康行

  萬有製薬株式会社 開発研究所

• 石井 美樹夫

  萬有製薬株式会社 開発研究所

• 高野 照和

  萬有製薬株式会社 開発研究所

• 今垣 和秀

  萬有製薬株式会社 開発研究所

• 畑 俊輔

  萬有製薬株式会社 開発研究所

• 大柴 進

  千曲台診療所

書誌事項

タイトル別名

• Pharmacokinetics of Finasteride in the Elderly Volunteers.

抄録

The pharmacokinetics of finasteride was assessed in 12 elderly and 12 young/ middle-aged volunteers following single oral administration of 5-mg drug.<BR>A plasma concentration profile of finasteride in the elderly is similar to that in young/middle-aged volunteers. Although C_max (39.7 ng/ml) and AUC_0-∞ (267 ng·hr/ml) in elderly volunteers were slightly lower than those (44.7 ng/ml and 318 ng·hr/ml) in young/middle-aged volunteers, there were no significant differences in these parameters between two groups. Also, there were no significant age-related differences in other pharmacokinetic parameters such as T_max MRT and t_1/2.<BR>Urinary concentrations of metabolites, ω-hydroxylated finasteride (M-1) and finasteride ω-oic acid (M-3), were also determined. Metabolite M-1 was not detected in any urine samples. Approximately 26.8% of the dose was excreted in urine as M-3 in the elderly, and 23.1% of the dose in young/middle-aged volunteers.<BR>These results suggest that the metabolism and disposition of finasteride are similar in the elderly and young/middle-aged volunteers after single oral administration.

収録刊行物

• 薬物動態

  薬物動態 10 (2), 197-204, 1995

  日本薬物動態学会

キーワード

• Finasteride
• 5α-Reductase inhibitor
• Elderly
• Pharmacokinetics
• Metabolites

詳細情報

• CRID: 1390001204670326528
• NII論文ID: 10007372898
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.10.197
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/10/2/10_2_197/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996143831
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可