マイタケ投与が高血圧自然発症ラットの血圧及び体重に及ぼす影響  [in Japanese] Effects of Administration of Grifola frondosa on Blood Pressure and Body Weight in Spontaneously Hypertensive Rats  [in Japanese]

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Abstract

マイタケを飼料重量に対して,10%と20%になるように調製した実験区を設け,高血圧自然発症ラット(SHR)に投与し,ラットの体重,血圧及び血液の性状,臓器に及ぼす影響について検討した.さらに,試料マイタケの加熱,エタノール抽出,水抽出による操作の影響をウイスター系ラットの体重増加により調べた.<BR>その結果,マイタケ投与によるラットの顕著な体重増加抑制効果と血圧上昇抑制効果が見られた.臓器の重量の比較ではマイタケ投与群で肝臓に僅かな低下が見られたが,他の臓器では影響は見られなかった.血液の性状では,マイタケ投与群で,血漿総コレステロール,中性脂肪の低下が見られ,20%投与群では,糞中へのコレステロールの排泄の増加も見られた.<BR>マイタケ中には血圧上昇抑制を示すなど各種の生理活性を有する成分が含有され,特に体重増加抑制を示す成分は,水可溶性で熱に不安定であることが明らかとなった.

We examined the effects of Maitake (Grifola frondosa) on body weight, blood pressure and biochemical components of blood in spontaneously hypertensive rats (SHR) for 37 days. Rats fed control diets containing powdered Maitake 10% level (M 10) and 20% level (M 20) showed suppressed body weight and blood pressure. No difference in organ weights was found among the three groups except for the liver, the weight of which in the Maitake groups was lower than that of the control. The Maitake groups showed lower total cholesterol and triglyceride in the blood and increased total cholesterol in the feces. The weight-reducing effect did not appear in rats administered heat-treated Maitake, a residue of Maitake extracted with water, and the ethanol-soluble fraction of Maitake. Only Maitake extract with cold water provided an evident weight-reducing effect. From these results, we concluded that Maitake contains a water-soluble, heat-labile substance that can suppress body weight and blood pressure.

Journal

  • Nippon Shokuhin Kagaku Kogaku Kaishi

    Nippon Shokuhin Kagaku Kogaku Kaishi 46(12), 806-814, 1999-12-15

    Japanese Society for Food Science and Technology

References:  21

Cited by:  2

Codes

  • NII Article ID (NAID)
    10007589844
  • NII NACSIS-CAT ID (NCID)
    AN10467499
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1341027X
  • NDL Article ID
    4937690
  • NDL Source Classification
    ZP34(科学技術--食品工学・工業)
  • NDL Call No.
    Z17-126
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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