複雑性尿路感染症に対するNM441の臨床的検討  [in Japanese] Clinical study of NM441 in complicated urinary tract infections  [in Japanese]

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Abstract

新規な経口キノロン系抗菌薬であるNM441を複雑性尿路感染症6例に投与し, 臨床的検討を行った. 主治医判定による6例の臨床効果は, 「有効」4例, 「無効」2例であった. このうちUTI薬効評価基準を適用できる5例の総合臨床効果は, 「著効」2例, 「無効」3例であった. 細菌学的には, 5例より10菌種10株が分離され, そのうち7株が除菌された. 自他覚的副作用では, 1例に軽度のめまいが認められたが, すぐに消失し, 継続投与可能であった. 臨床検査値の異常変動は認められなかった.

NM441, a new developed oral quinolone antibiotic, was administered to 6 patients with complicated urinary tract infections, and a clinical study was performed.<BR>The clinical response according to the doctor's evaluation was good in 4 cass and poor in 2 of 6 patients. According to the criteria of the Japanese UTI Committee, 5 patients were evaluable, and the overall clinical response was excellent in 2 cases and poor in 3. In bacteriological efficacy, 10 strains of 10 species of organisms were isolated from 5 patients, and 7 strains of them were eradicated. As for subjective or objective side effects, mild dizziness was observed in 1 case, but it disappeared immediately and the treatment was continued. No abnormal changes in laboratory findings were observed.

Journal

  • Japanese Journal of Chemotherapy

    Japanese Journal of Chemotherapy 44, 692-694, 1996-03-01

    Japanese Society of Chemotherapy

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