Comparative Biochemistry of Disintegrins Isolated from Snake Venom : Consideration of the Taxonomy and Geographical Distribution of Snakes in the Genus Echis

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Author(s)

Abstract

Species in the genus <i>Echis</i> have been classified mainly based on their morphological appearance and the analytical patterns of their serum. However, re-classification of the genus <i>Echis</i> has recently been suggested by taxonomists, toxicologists, and clinicians, since there have been problems with the current classification, such as the efficacy of antivenoms used for treating bites and the broad geographical distribution of <i>Echis</i> snakes. In this study, we purified five novel disintegrins, the platelet aggregation inhibitors pyramidin A and B from the venom of <i>Echis pyramidum</i>, ocellatin from the venom of <i>Echis ocellatus</i>, and leucogastin A and B from the venom of <i>Echis leucogaster</i>, to compare their sequences and allow us to re-evaluate the classification of various species in the genus <i>Echis</i>. Comparison of the amino acid sequences of five new and four known isolated disintegrins from snake venoms of six <i>Echis</i> species and their distribution strongly support the recent re-classification of the genus <i>Echis</i>.

Journal

  • The Journal of Biochemistry

    The Journal of Biochemistry 129(4), 615-620, 2001-04-01

    The Japanese Biochemical Society

References:  29

Codes

  • NII Article ID (NAID)
    10007854751
  • NII NACSIS-CAT ID (NCID)
    AA00694073
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    0021924X
  • NDL Article ID
    5729713
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B472
  • Data Source
    CJP  NDL  J-STAGE 
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