大腸癌におけるリンパ節転移様式: 経過予測因子としての意義

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  • Mode of Metastasis of Dukes C Colorectal Cancer in Lymph Nodes.

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Lymph node metastasis positive cases of colorectal cancer (Dukes C) were classified by the mode of lymph node metastases into intranodal and extranodal types, and their correlation with the prognosis and rates of hepatic metastases were investigated.<BR>The subjects were 451 out of 492 cases of primary colorectal cancer which underwent surgery between 1977 and 1990.<BR>The lymph node metastasis positive cases were classified into the following 2 groups : 1) The intranodal type (IN) in which metastatic cancer was localized in the lymph nodes with no capsular or extracapsular infiltration, and 2) the extra nodal type (EN) in which the metastatic cancer was extended to the extracapsular adipose tissue or the extracapsular vessels (blood or lymph vessels).<BR>The 5-year survival rate was 62.3% for the IN type and 26.0% for the EN type, and the rate of hepatic metastases was 6/52 (11.5%) for the IN type and 49/145 (33.8%) for the EN type with a significant differences between the rates for each type in both tests.

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