Controlled Release of Nifedipine from Coevaporates Prepared with Eudragit and Poloxamer

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<p>Nifedipine (NP)-Eudragit (ERS or ERL)-Poloxamer 188 (PXM) solid dispersions were prepared by coevaporation technique and the physicochemical properties of the coevaporates were characterized. The X-ray diffraction and the differential scanning calorimetric studies gave the results that NP existed in amorphous state in the coevaporates in which NP content was less than approximately 17% regardless of the type of Eudragit and PXM content in combined carriers. Interaction between NP and Eudragit was speculated from the infrared spectral change of C=O stretching vibration. The effects of the type of Eudragit, NP: carrier mixing ratio and PXM content in combined carrier on NP release profile were determined. The drug release mechanism was demonstrated to follow diffusion-controlled kinetics. The scanning electron microphotographs of certain coevaporates after the dissolution process confirmed the diffusion-controlled mechanism of NP release. From the dissolution efficiency, the time for 50% drug dissolution and the dissolution rate constant, it was demonstrated that the controlled release of NP could be accomplished in the coevaporates of combined carriers. The ERL showed the more prominent possibility for the formulation of controlled release of NP.</p>

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  • 薬剤学

    薬剤学 61 (1), 21-33, 2001

    公益社団法人 日本薬剤学会

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