Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. for Skin Depigmentation

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Abstract

Six compounds were isolated from the leaves of Celosia argentea L.. Tyrosinase inhibitory and superoxide scavenging activity of the compounds was examined so as to obtain a skin depigmentation agent for cosmetic application. Eugenyl O-β-D-glucopyranoside (citrusin C, 1) showed strong tyrosinase inhibitory activity. Two-step inhibitory effects of successive tyrosine and DOPA oxidation for tyrosinase were stronger compared to arbutin used commercially at present (47.20% inhibition of tyrosine oxidation and 87.93%, DOPA oxidation, compared to 63.00% for tyrosine and 7.70% for DOPA oxidation in the case of arbutin). Moreover, we succeed in providing compound 1 abundantly in the synthetic study which used acetobromo-α-D-glucose and Sn(OTf)<SUB>2</SUB>.

Journal

  • Journal of Oleo Science

    Journal of Oleo Science 51(3), 203-206, 2002-03-01

    Japan Oil Chemists' Society

References:  11

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008009780
  • NII NACSIS-CAT ID (NCID)
    AA11503337
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13458957
  • NDL Article ID
    6066841
  • NDL Source Classification
    ZP25(科学技術--化学・化学工業--油脂類)
  • NDL Call No.
    Z54-J571
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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