Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. for Skin Depigmentation.

• SAWABE Akiyoshi

  Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University

• NOMURA Masato

  Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University

• FUJIHARA Yoshihito

  Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University

• TADA Takahiro

  Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.

• HATTORI Fumihiro

  Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.

• SHIOHARA Satoko

  Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.

• SHIMOMURA Kenji

  Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.

• MATSUBARA Yoshiharu

  Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University

• KOMEMUSHI Sadao

  Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University

• OKAMOTO Tadashi

  Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University

• KAWAMURA Saburou

  Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University

Abstract

Six compounds were isolated from the leaves of Celosia argentea L.. Tyrosinase inhibitory and superoxide scavenging activity of the compounds was examined so as to obtain a skin depigmentation agent for cosmetic application. Eugenyl O-β-D-glucopyranoside (citrusin C, 1) showed strong tyrosinase inhibitory activity. Two-step inhibitory effects of successive tyrosine and DOPA oxidation for tyrosinase were stronger compared to arbutin used commercially at present (47.20% inhibition of tyrosine oxidation and 87.93%, DOPA oxidation, compared to 63.00% for tyrosine and 7.70% for DOPA oxidation in the case of arbutin). Moreover, we succeed in providing compound 1 abundantly in the synthetic study which used acetobromo-α-D-glucose and Sn(OTf)₂.

Journal

• Journal of Oleo Science

  Journal of Oleo Science 51 (3), 203-206, 2002

  Japan Oil Chemists' Society

Keywords

• citrusin C
• eugenyl O-β-D-glucopyranoside
• skin depigmentation effect
• tyrosinase inhibitory activity
• superoxide scavenging activity

Details

• CRID: 1390282679068496896
• NII Article ID: 10008009780
• NII Book ID: AA11503337
• DOI: 10.5650/jos.51.203
• ISSN: 13473352
• ISSN: 13458957
• NDL BIB ID: 6066841
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6066841
• Web Site: https://www.jstage.jst.go.jp/article/jos/51/3/51_3_203/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed