生体膜とガス [in Japanese] Biomembranes and Gases [in Japanese]
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Besides O<SUB>2</SUB> and CO<SUB>2</SUB>, many small molecules can be transferred between respiratory gases and blood. There is an alveocapillary membrane between respiratory gases and blood, that consists of alveolar epithelium and capillary endothelium, and gases should transfer via these cell membranes. Artificial lungs consist of polypropylene membranes, of which the thickness is nearly the same as that of the thin portion of the alveocapillary membrane in natural lungs (-0.5μm).<BR>Volatile anesthetics are administered with inspired gas, and anesthetic molecules transter and interact with biomembranes to cause anesthesia. Both the interactions between anesthetics and functional proteins and those between anesthetics and membrane lipids are important to induce anesthesia. Membrane lipids are not simply the supporting matrix of the functional proteins, they also sometimes control the function of proteins.<BR>In patients poisoned with volatile compounds, some of the compounds are usually eliminated in the expired gas. Since the method of obtaining expired gas is the least invasive, it may be the most practical sample to monitor cases of poisoning.<BR>The gas transfer at alveolar provides much useful information about the body condition.
MEMBRANE 26(2), 72-78, 2001-03-01
THE MEMBRANE SOCIETY OF JAPAN