細胞膜分子の膜骨格による組織化機構 : 一分子法によるアプローチ  [in Japanese] Regulation Mechanisms for Molecular Diffusion in the Cell Membrane by the Membrane Skeleton : A Single Molecule Approach  [in Japanese]

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Author(s)

    • 村瀬 琴乃 MURASE Kotono
    • 名古屋大学大学院理学研究科生命理学専攻超分子システム研究グループ Department of Biological Science, Nagoya University
    • RITCHIE Ken RITCHIE Kenneth
    • 名古屋大学大学院理学研究科生命理学専攻超分子システム研究グループ Department of Biological Science, Nagoya University
    • 藤原 敬宏 [他] FUJIWARA Takahiro
    • 科学技術振興事業団創造科学技術振興事業楠見膜組織能プロジェクト Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology Organization (ERATO), Japan Science and Technology Corporation
    • 飯野 亮太 IINO Ryota
    • 科学技術振興事業団創造科学技術振興事業楠見膜組織能プロジェクト Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology Organization (ERATO), Japan Science and Technology Corporation
    • 中田 千枝子 NAKADA Chieko
    • 科学技術振興事業団創造科学技術振興事業楠見膜組織能プロジェクト Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology Organization (ERATO), Japan Science and Technology Corporation
    • 楠見 明弘 KUSUMI Akihiro
    • 名古屋大学大学院理学研究科生命理学専攻超分子システム研究グループ Department of Biological Science, Nagoya University

Abstract

Single particle tracking (SPT), laser tweezers, and single fluorophore video imaging (SFVI) have facilitated observation of molecular interactions in the plasma membrane of living cells at a level of single molecules. These techniques revealed that the membrane skeleton provides both corralling and binding effects on the movement of membrane proteins and lipids. Corralled membrane proteins undergo hop diffusion from one compartment to an adjacent one (membrane skeleton fence model). Lipids macroscopic diffusion is also largely limited by the hop rate across the compartment boundaries formed by rows of pickets made of various transmembrane proteins anchored to the actin membrane skeleton (anchored-protein picket model). These mechanisms can play a pivotal role in the molecular organization of the plasma membrane.

Journal

  • MEMBRANE

    MEMBRANE 27(2), 58-66, 2002-03-01

    THE MEMBRANE SOCIETY OF JAPAN

References:  16

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008011093
  • NII NACSIS-CAT ID (NCID)
    AN0023215X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03851036
  • NDL Article ID
    6123699
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z18-1127
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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