細胞膜リン脂質のダイナミズムを介した膜と細胞骨格のクロストーク  [in Japanese] Membrane Phospholipids in Cytoskeletal Organizations  [in Japanese]

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Author(s)

    • 榎本 和生 EMOTO Kazuo
    • 東京都臨床医学総合研究所炎症研究部門 Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science
    • 梅田 真郷 UMEDA Masato
    • 東京都臨床医学総合研究所炎症研究部門 Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science

Abstract

Phosphatidylethanolamine (PE) is a major membrane phospholipid that is mainly localized in the internal leaflet of the plasma membrane. We have shown that PE was exposed on the external leaflet of the cleavage furrow as a result of enhanced transbilayer movement of the phospholipids during cytokinesis. To further investigate the role of PE in cytokinesis, we employed two different approaches : manipulation of cell surface PE by a PE-binding peptide, and the establishment of a mutant cell line specifically defective in PE biosynthesis. Both approaches clearly demonstrate that surface-exposed PE is essential for disassembly of the contractile ring at the final stage of cytokinesis. Based on these findings, we proposed that the transbilayer redistribution of PE plays a critical role in mediating coordinated movements between the cytoskeleton and the plasma membrane that are required for the proper progression of cytokinesis.

Journal

  • MEMBRANE

    MEMBRANE 27(2), 67-73, 2002-03-01

    THE MEMBRANE SOCIETY OF JAPAN

References:  11

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008011110
  • NII NACSIS-CAT ID (NCID)
    AN0023215X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03851036
  • NDL Article ID
    6123731
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z18-1127
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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