細胞膜リン脂質のダイナミズムを介した膜と細胞骨格のクロストーク Membrane Phospholipids in Cytoskeletal Organizations

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著者

    • 榎本 和生 EMOTO Kazuo
    • 東京都臨床医学総合研究所炎症研究部門 Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science
    • 梅田 真郷 UMEDA Masato
    • 東京都臨床医学総合研究所炎症研究部門 Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science

抄録

Phosphatidylethanolamine (PE) is a major membrane phospholipid that is mainly localized in the internal leaflet of the plasma membrane. We have shown that PE was exposed on the external leaflet of the cleavage furrow as a result of enhanced transbilayer movement of the phospholipids during cytokinesis. To further investigate the role of PE in cytokinesis, we employed two different approaches : manipulation of cell surface PE by a PE-binding peptide, and the establishment of a mutant cell line specifically defective in PE biosynthesis. Both approaches clearly demonstrate that surface-exposed PE is essential for disassembly of the contractile ring at the final stage of cytokinesis. Based on these findings, we proposed that the transbilayer redistribution of PE plays a critical role in mediating coordinated movements between the cytoskeleton and the plasma membrane that are required for the proper progression of cytokinesis.

収録刊行物

  • 膜 27(2), 67-73, 2002-03-01

    THE MEMBRANE SOCIETY OF JAPAN

参考文献:  11件中 1-11件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008011110
  • NII書誌ID(NCID)
    AN0023215X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03851036
  • NDL 記事登録ID
    6123731
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1127
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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