Membrane Phospholipids in Cytoskeletal Organizations.

• Emoto Kazuo

  Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science

• Umeda Masato

  Department of Molecular Biodynamics, The Tokyo Metropolitan Institute of Medical Science

Bibliographic Information

Other Title

• 生体膜と細胞骨格系の機能的相互作用　　細胞膜リン脂質のダイナミズムを介した膜と細胞骨格のクロストーク
• サイボウマク リン シシツ ノ ダイナミズム オ カイシタ マク ト サイボウ コッカク ノ クロストーク

Abstract

Phosphatidylethanolamine (PE) is a major membrane phospholipid that is mainly localized in the internal leaflet of the plasma membrane. We have shown that PE was exposed on the external leaflet of the cleavage furrow as a result of enhanced transbilayer movement of the phospholipids during cytokinesis. To further investigate the role of PE in cytokinesis, we employed two different approaches : manipulation of cell surface PE by a PE-binding peptide, and the establishment of a mutant cell line specifically defective in PE biosynthesis. Both approaches clearly demonstrate that surface-exposed PE is essential for disassembly of the contractile ring at the final stage of cytokinesis. Based on these findings, we proposed that the transbilayer redistribution of PE plays a critical role in mediating coordinated movements between the cytoskeleton and the plasma membrane that are required for the proper progression of cytokinesis.

Journal

• MEMBRANE

  MEMBRANE 27 (2), 67-73, 2002

  THE MEMBRANE SOCIETY OF JAPAN

Keywords

• phospholipid asymmetry
• actin filament
• cell division
• phospholipid-binding probe

Details

• CRID: 1390282681399827840
• NII Article ID: 10008011110
• NII Book ID: AN0023215X
• DOI: 10.5360/membrane.27.67
• ISSN: 18846440
• ISSN: 03851036
• NDL BIB ID: 6123731
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6123731
• Web Site: https://search.jamas.or.jp/link/ui/2002186696
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed