Effect of Supplementation of Vitamin E and Vitamin C on Brain Acetylcholinesterase Activity and Neurotransmitter Levels in Rats Treated with Scopolamine, an Inducer of Dementia

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Author(s)

Abstract

In the resent study, the effects of vitamins E and C on the levels of neuro- transmitters and acetylcholinesterase activity in the brains of rats treated with scopo-lamine, an inducer of dementia, were examined. Fifty male Sprague-Dawley rats at the age of 5 wk were divided into five groups after 1 wk of adaptation and fed five different diets for 6 wk: a no-scopolamine group, which was a scopolamine-untreated group fed only a basal diet; a scopolamine-treated group fed a basal diet; a vitamin E-supplemented scopolamine-treated group; a vitamin <i>C</i>-supplemented scopolamine-treated group; and a vitamins E and <i>C</i>-supplemented scopolamine-treated group. Scopolamine was twice administered by in-traperitoneal injection (300 mg/kg, body weight), 3 d and 20 min prior to sacrifice. Brain acetylcholinesterase activity was markedly reduced by scopolamine injection. However, the supplementation of vitamins E and C in the diet significantly increased the reduced brain acetylcholinesterase activity up to the level of the scopolamine-untreated group. Brain sero-tonin concentration in the vitamin <i>C</i>-supplemented scopolamine-treated group was signifi-cantly higher than that in the scopolamine-treated group. However, there were no signifi-cant differences in brain dopamine and norepinephrine concentrations among all groups. In, conclusion, supplementation with vitamin E and/or vitamin C might be useful in main-taining brain acetylcholinesterase activity at the normal level and serotonin concentration for some extent under the condition to induce dementia by scopolamine administration.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 47(5), 323-328, 2001-10-01

    Center for Academic Publications Japan

References:  41

Codes

  • NII Article ID (NAID)
    10008015587
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    03014800
  • NDL Article ID
    5988737
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  NDL  J-STAGE 
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