Effect of Supplementation of Vitamin E and Vitamin C on Brain Acetylcholinesterase Activity and Neurotransmitter Levels in Rats Treated with Scopolamine, an Inducer of Dementia.
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- LEE Lilha
- Department of Home Economics Education
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- KANG Soon Ah
- Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University
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- LEE Hyun Ok
- Department of Food and Nutrition, Chung-Ang University
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- LEE Bog-Hieu
- Department of Food and Nutrition, Chung-Ang University
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- JUNG In Kyung
- Department of Home Economics Education
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- LEE Ji Eun
- Department of Home Economics Education
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- HEO Young-Su
- Department of Food and Nutrition, Chung-Ang University
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In the resent study, the effects of vitamins E and C on the levels of neuro- transmitters and acetylcholinesterase activity in the brains of rats treated with scopo-lamine, an inducer of dementia, were examined. Fifty male Sprague-Dawley rats at the age of 5 wk were divided into five groups after 1 wk of adaptation and fed five different diets for 6 wk: a no-scopolamine group, which was a scopolamine-untreated group fed only a basal diet; a scopolamine-treated group fed a basal diet; a vitamin E-supplemented scopolamine-treated group; a vitamin C-supplemented scopolamine-treated group; and a vitamins E and C-supplemented scopolamine-treated group. Scopolamine was twice administered by in-traperitoneal injection (300 mg/kg, body weight), 3 d and 20 min prior to sacrifice. Brain acetylcholinesterase activity was markedly reduced by scopolamine injection. However, the supplementation of vitamins E and C in the diet significantly increased the reduced brain acetylcholinesterase activity up to the level of the scopolamine-untreated group. Brain sero-tonin concentration in the vitamin C-supplemented scopolamine-treated group was signifi-cantly higher than that in the scopolamine-treated group. However, there were no signifi-cant differences in brain dopamine and norepinephrine concentrations among all groups. In, conclusion, supplementation with vitamin E and/or vitamin C might be useful in main-taining brain acetylcholinesterase activity at the normal level and serotonin concentration for some extent under the condition to induce dementia by scopolamine administration.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 47 (5), 323-328, 2001
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詳細情報 詳細情報について
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- CRID
- 1390282681302982784
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- NII論文ID
- 10008015587
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 5988737
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- PubMed
- 11814146
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可