Effect of Supplementation of Vitamin E and Vitamin C on Brain Acetylcholinesterase Activity and Neurotransmitter Levels in Rats Treated with Scopolamine, an Inducer of Dementia.

• LEE Lilha

  Department of Home Economics Education

• KANG Soon Ah

  Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University

• LEE Hyun Ok

  Department of Food and Nutrition, Chung-Ang University

• LEE Bog-Hieu

  Department of Food and Nutrition, Chung-Ang University

• JUNG In Kyung

  Department of Home Economics Education

• LEE Ji Eun

  Department of Home Economics Education

• HEO Young-Su

  Department of Food and Nutrition, Chung-Ang University

抄録

In the resent study, the effects of vitamins E and C on the levels of neuro- transmitters and acetylcholinesterase activity in the brains of rats treated with scopo-lamine, an inducer of dementia, were examined. Fifty male Sprague-Dawley rats at the age of 5 wk were divided into five groups after 1 wk of adaptation and fed five different diets for 6 wk: a no-scopolamine group, which was a scopolamine-untreated group fed only a basal diet; a scopolamine-treated group fed a basal diet; a vitamin E-supplemented scopolamine-treated group; a vitamin C-supplemented scopolamine-treated group; and a vitamins E and C-supplemented scopolamine-treated group. Scopolamine was twice administered by in-traperitoneal injection (300 mg/kg, body weight), 3 d and 20 min prior to sacrifice. Brain acetylcholinesterase activity was markedly reduced by scopolamine injection. However, the supplementation of vitamins E and C in the diet significantly increased the reduced brain acetylcholinesterase activity up to the level of the scopolamine-untreated group. Brain sero-tonin concentration in the vitamin C-supplemented scopolamine-treated group was signifi-cantly higher than that in the scopolamine-treated group. However, there were no signifi-cant differences in brain dopamine and norepinephrine concentrations among all groups. In, conclusion, supplementation with vitamin E and/or vitamin C might be useful in main-taining brain acetylcholinesterase activity at the normal level and serotonin concentration for some extent under the condition to induce dementia by scopolamine administration.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 47 (5), 323-328, 2001

  一般財団法人 学会誌刊行センター

キーワード

• acetylcholinesterase activity
• vitamin E
• vitamin C
• neurotransmitter
• scopo-lamine

詳細情報

• CRID: 1390282681302982784
• NII論文ID: 10008015587
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.47.323
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 5988737
• PubMed: 11814146
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5988737
• Web Site: https://search.jamas.or.jp/link/ui/2002134294
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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