Hypoglycemic Activity of the Fruit of the Momordica charantia in Type 2 Diabetic Mice

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Author(s)

Abstract

The antidiabetic activity of <i>Momordica charantia</i> L. (Cucurbitaceae) was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of <i>Momordica charantia</i> L. (MC) reduced the blood glucose of KK-Ay mice 3 weeks after oral administration (<i>p</i><0.01) and also significantly lowered the serum insulin of KK-Ay mice under similar conditions (<i>p</i><0.01). However, MC did not affect the blood glucose in normal mice. MC-treated KK-Ay mice blood glucose significantly decreased in an insulin tolerance test. Moreover, the muscle content of facilitative glucose transporter isoform 4 (GLUT4) protein content in the plasma membrane fraction from muscle significantly increased in the orally MC-treated mice when compared with that of the controls (<i>p</i><0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from a decrease in insulin resistance because of the increase of GLUT4 protein content in the plasma membrane of the muscle.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 47(5), 340-344, 2001-10-01

    Center for Academic Publications Japan

References:  26

Cited by:  5

Codes

  • NII Article ID (NAID)
    10008015680
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03014800
  • NDL Article ID
    5988759
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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