Protective Effects of Hot Water Extract of Safflower Leaves and Its Component Luteolin-7-O-Glucoside on Paraquat-Induced Oxidative Stress in Rats.

• IGARASHI Kiharu

  Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University

• DEMACHI Akiko

  Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University

• TAKENAKA Asako

  Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University

抄録

Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). Both Ex and LuGlc suppressed lowering of food intake, and body weight gain, increases in lung weight, liver thiobarbituric acid reactive substances (TBARS), and a decrease in the liver triacylglycerol concentration were all induced by PQ-feeding. Rises in the liver total glutathione and oxidized glutathione concentrations in the PQ-fed rats were suppressed by adding Ex and LuGlc to the PQ diet. Moreover, Ex and LuGlc tended to suppress decreases in catalase activity in the liver mitochondrial fraction and liver α-tocopherol concentration which were induced by PQ-feeding. These results showed that both Ex and LuGlc, which is a major component of Ex, may be available to suppress oxidative stress in vivo.<br>

収録刊行物

• Food Science and Technology Research

  Food Science and Technology Research 7 (3), 224-230, 2001

  公益社団法人 日本食品科学工学会

キーワード

• safflower leaves
• luteolin-7-O-glucoside
• paraquat
• oxidative stress

詳細情報

• CRID: 1390282679431351936
• NII論文ID: 10008015977
• NII書誌ID: AA11267620
• DOI: 10.3136/fstr.7.224
• COI: 1:CAS:528:DC%2BD3MXos12murw%3D
• ISSN: 18813984
• ISSN: 13446606
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可