セフェム耐性大腸菌に対するｃｅｆｔｅｒａｍ　ｐｉｖｏｘｉｌのｉｎ　ｖｉｔｒｏおよびｉｎ　ｖｉｖｏ抗菌活性

• 荒木 春美

  富山化学工業株式会社綜合研究所

• 西田 亨子

  富山化学工業株式会社綜合研究所

• 大懸 直子

  富山化学工業株式会社綜合研究所

• 南 新三郎

  富山化学工業株式会社綜合研究所

書誌事項

タイトル別名

• In vitro and in vivo antibacterial activity of cefteram pivoxil against cephem-resistant Escherichia coli.

抄録

In vitro and in vivo antibacterial activity of cefteram pivoxil was studied using 37 clinical isolates of cephem-resistant Escherichia coli (cefaclor; MIC>12.5μg/mL) and compared to those of other oral antibacterial agents. MIC₉₀ of cefteram (the active form of cefteram pivoxil) against cephem-resistant E.coli (37 strains) was 3.13μg/mL and less than those of cefiditoren (6.25μg/mL), cefpodoxime (25μg/mL), cefdinir (25μg/mL), cefixime (50μg/mL), amoxicillin (>100μg/mL), and cefaclor (>100μg/mL) and comparable to that of norfloxacin (3.13μg/mL). MIC₉₀s of tested drugs against 25 strains of cephem-susceptible E. coli were as follows: cefditoren (0.2μg/mL), cefixime (0.39μg/mL), cefteram (0.78μg/mL), cefpodoxime (3.13μg/mL), cefdinir (3.13μg/mL), cefaclor (3.13μg/mL), and amoxicillin (3.13μg/mL). The difference between MIC₉₀s against cephem-resistant and susceptible E. coli was lowest for cefteram. No cephem-resistant strains showed hydrolytic activity against the cephems tested except for cefaclor. The therapeutic effect of cefteram pivoxil against an experimental mouse urinary tract infection caused by cephem-resistant E.coli TK-776 was superior to that of cefdinir, cefditoren, cefixime, and cefaclor, reflecting its in vitro activity.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 50 (1), 25-28, 2002

  公益社団法人 日本化学療法学会

キーワード

• セフェム耐性
• 抗菌活性

詳細情報

• CRID: 1390001206285788416
• NII論文ID: 10008028825
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.50.25
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2002165217
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可