新鮮臨床分離株に対するgatifloxacinの抗菌活性

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  • Antimicrobial activities of gatifloxacin against clinical isolates

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In order to evaluate the antibacterial spectrum and antimicrobial activity of gatifloxacin (GFLX), minimum inhibitory concentrations (MICs) of GFLX and control drugs were determined against standard strains and clinical isolates that were obtained by our laboratory in 1995.<BR>Results are summarized as follows:<BR>1.Antimicrobial activity of GFLX against Streptococcus spp.(including Streptococcus pneumoniae and Streptococcus pyogenes) and Peptostreptococcus spp.was equal to or stronger than that of tosufloxacin (TFLX), and was stronger than that of levofloxacin (LVFX) and ciprofloxacin (CPFX).<BR>2.Antimicrobial activity of GFLX against the Bacteroides fragilis group and Prevotella spp.was clearly stronger than that of TFLX, LVFX and CPFX.<BR>3.The results of antimicrobial activity against Staphylococcus spp., Enterococcus spp.and quinolonesresistant Enterobacteriaceae suggest that GFLX shows strong antimicrobial activity against fluoroquinolone-resistant strains.<BR>4.Antimicrobial activity of GFLX against Pseudomonas aeruginosa was approximately equal to that of other fluoroquinolones, and its antimicrobial activity against other glucose-nonfermentative Gram-negative rods was strong.

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