健常成人におけるgatifloxacinの体内動態に及ぼす鉄剤の併用, 並びに緑茶または牛乳による服薬の影響

• 柴 孝也

  東京慈恵会医科大学内科学講座第三

書誌事項

タイトル別名

• Effects of ferrous sulfate, green tea, and milk on the pharmacokinetics of gatifloxacin in healthy humans

抄録

We investigated the effects of concomitant medication of 160 mg of ferrous sulfate (FeSO₄), and drug intake with green tea or milk on the pharmacokinetics of 200 mg of gatifloxacin (GFLX) in six healthy male volunteers. The peak serum concentration of unchanged drug and the area under the serum concentration-time curve (AUC_0-∞) decreased from 1.97 to 1.00 μg/mL and from 14.2 to 10.1 μg·h/mL, respectively, and the urinary excretion of GFLX over 48 h decreased from 80.8% to 65.2% of dose with FeSO₄ On the other hand, these parameters were not changed with green tea and milk, except for the slight reduction of AUC_0-∞ to 12.0 μg·h/mL with milk. These results indicated that concomitant medication of FeSO₄ decreased the absorption of GFLX, but that intake with green tea and milk had little effect on the pharmacokinetics of GFLX in humans.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 47 (Supplement2), 224-229, 1999

  公益社団法人 日本化学療法学会

キーワード

• 鉄剤
• 緑茶
• 牛乳
• 体内動態

詳細情報

• CRID: 1390282681266347392
• NII論文ID: 10008029179
• NII論文ID: 130004297953
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.47.supplement2_224
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2000041443
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可