An Autopsy Case of POEMS Syndrome with a High Level of IL-6 and VEGF in the Serum and Ascitic Fluid

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Author(s)

Abstract

A 45-year-old woman was hospitalized because of systemic edema and peripheral nerve impairment. The patient had complications of organomegaly, endocrinopathy, and monoclonal gammmopathy, and was diagnosed with PO-EMS syndrome based on these characteristic signs and symptoms. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) levels in the serum and ascitic fluid were high. Many of the patient's symptoms were ameliorated, and IL-6 and VEGF levels in the serum and ascitic fluid decreased slightly during chemotherapy, but she died of respiratory failure. Autopsy revealed severe systemic edema and macroscopic hemorrhage in many organs, but VEGF and IL-6 producing cells were not found.<br>(Internal Medicine 41: 233-236, 2002)

Journal

  • Internal Medicine

    Internal Medicine 41(3), 233-236, 2002-03

    The Japanese Society of Internal Medicine

References:  18

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008034583
  • NII NACSIS-CAT ID (NCID)
    AA10827774
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09182918
  • NDL Article ID
    6262893
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z53-M398
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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