夫婦で発症した非Hodgkinリンパ腫の2組 [in Japanese] Non-Hodgkin's lymphoma in two married couples [in Japanese]
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夫婦1: 74歳女性，左腋窩リンパ節生検にてdiffuse large B-cell lymphoma (DLBL)と診断された。約6カ月後に79歳の夫が右下顎リンパ節生検にてDLBLと診断された。妻は部分寛解となったが再燃し死亡，夫は寛解に至らず腎不全にて死亡した。夫婦2: 86歳男性，左腋窩リンパ節生検を施行され，DLBLと診断された。約4年後に86歳の妻が左腋窩リンパ節生検にてDLBLと診断された。化学療法を施行，夫は完全寛解となり生存中であり，妻は部分寛解となったが再燃し死亡した。われわれの症例では，EBウイルスやHTLV-Iが発症に関与しているという可能性は考えにくく，また環境因子の関与も確認されなかった。ほかの未知の因子の存在が夫婦間のリンパ腫の発症に関連している可能性もあるのではないかと思われた。
Couple 1: A 74-year-old woman was diagnosed as having diffuse large B-cell lymphoma (DLBL) by left axillary lymph node biopsy. About 6 months later, DLBL was also diagnosed in her 79-year-old husband by right submandibular lymph node biopsy. Although the wife achieved partial remission with chemotherapy, she died due to disease progression. The husband's disease was chemotherapy-resistant, and he died of renal failure. Couple 2: An 86-year-old man was diagnosed as having DLBL by left axillary lymph node biopsy. About 4 years later, DLBL was also diagnosed in his 86-year-old wife by left axillary lymph node biopsy. Both the husband and the wife received chemotherapy. The husband is currently alive in complete remission, and although the wife achieved partial remission, she died due to disease progression. In both of these couples, it was considered unlikely that Epstein-Barr virus or human T-cell lymphotropic virus type I was related to the development of non-Hodgkin's lymphoma, and no environmental factors were confirmed to be involved. It is postulated that other unknown factors or agents may be associated with the development of lymphoma in married couples.
- Rinsho Ketsueki
Rinsho Ketsueki 41(8), 641-647, 2000-08-30
The Japanese Society of Hematology